Bacteriophage genomics uses DNA sequencing and comparative analysis to understand the diversity, evolution, and biology of viruses that infect bacteria. By analysing phage genomes at scale, we can uncover how phages interact with their hosts, how they evolve, and how their genetic features shape microbial communities.
In the Millard Lab, based at the University of Leicester, we apply high-throughput sequencing and bioinformatics to study bacteriophages from clinical, environmental, and experimental systems. Our work spans individual genome characterisation through to large-scale comparative genomics across thousands of phages.
Key questions we address include how phage genomes are organised, how genes are gained or lost over, and how genome content relates to host range, lifestyle, and ecological function. We also focus on improving phage genome quality, annotation accuracy, and consistency across public databases.
Bacteriophage genomics underpins many downstream applications, including phage taxonomy, host prediction, viromics, and phage therapy research. By combining rigorous genome analysis with open data and reproducible workflows, we aim to build reliable genomic foundations that support both fundamental research and translational applications.